We share an article, recently published in SCIENCE Translational Medicine, which describes the first steps towards a non-invasive screening for ovarian cancer. In a proof-of-principle study Lara Paracchini and collaborators show how the research for "genomic instability" in the PAP test can anticipate, years in advance, the diagnosis of high-grade serous ovarian carcinoma, one of the most elusive and aggressive tumors.